"Could We Start Again, Please?" is the seventh episode of the eleventh season of Grey's Anatomy and the 227th produced episode of the series. It is also the 338th produced episode of the Grey's Anatomy franchise. It was broadcast on November 13, 2014.
When the doctors are faced with the survivors of a house fire, Amelia's tragic past comes back to haunt her when her patient's daughter exposes her addiction to the rest of the hospital's staff. As Amelia finds herself struggling with her past catching up with her, Owen's concerns about her surgical ability forces Derek to choose between protecting his sister or reclaiming leadership of his department. Meanwhile, Meredith tries to make amends with Maggie after their failed attempt at a family dinner and Bailey oversees Jo's first solo procedure, but Jo soon discovers that things may not have gone as smoothly as she first believed. Arizona, still reeling from Herman's life-altering revelation, finds herself forced into action when Herman takes an unexplained absence, leaving Arizona and April to fight for the life of an expectant mother and her child.
- "They say life doesn't give you second chances, but we do. Surgeons do. You break a bone, we put it back together. You bleed, we make it stop. You flatline, we resuscitate you. But as much as we give people second chances, surgeons don't usually get them, because the kind of mistakes we make, are sometimes impossible to recover from."
- "It's hard to give second chances. It's even harder to ask for them, a chance to do it again knowing what you know what, what you've learned. A chance to do it completely differently. A chance to right all wrongs, to try and correct our mistakes. A chance to try and start over from scratch."
- "Feed My Soul" - Lucy & The Cloud Parade
- "Medicine" - BROODS
- "Home" - Ella Ayre
This episode's title originated from the song Could We Start Again, Please?, originally from the musical Jesus Christ Superstar.