"Didn't We Almost Have It All?" is the twenty-fifth episode of the third season of Grey's Anatomy and the 61st produced episode of the series. It is also the 61st produced episode of the Grey's Anatomy franchise. It was broadcast on May 17, 2007.
A successor to the Cheif is announced as Cristina and Burke’s wedding day arrives. The interns hear back about their medical exams, George faces huge decisions about his future after Izzie makes a dramatic confession and Callie proposes they start a family together. Meredith and Derek’s relationship reaches a crossroads and Ava gives Alex and ultimatum.
- "Roboxula" - The Jealous Girlfriends
- "Falling Or Flying" - Grace Potter & The Nocturnals
- "Hold You In My Arms" - Ray LaMontagne
- "Closer" - Coburn
- "Within You" - Ray LaMontagne
- "Eulogy" - The Hereafter
- "Explosions" - The Mary Onettes
- "Keep Breathing" - Ingrid Michaelson
This episodes' title references the song Didn't We Almost Have It All?, originally sung by Whitney Houston
- This episode features no opening or closing voiceover.
- Last Appearance of Preston Burke