"Don't Dream It's Over" is the sixteenth episode of the eleventh season of Grey's Anatomy and the 236th produced episode of the series. It is also the 347th produced episode of the Grey's Anatomy franchise. It was broadcast on March 19, 2015.
An older man crashes a car into the house of a young, pregnant couple. It is quickly learned that the older man has Alzheimer's which brings back memories to Richard of his late wife, Adele. When the man wakes up from exploratory surgery, he seems magically cured of Alzheimer's but Amelia discovers that he suffers from NPH, which caused his memory loss. She offers to insert a shunt to prevent fluid from building up, but he denies, hoping to forget what he learns of the mother's fate. Initially, the young mother seems fine, but unbeknownst to her doctors, she is having a massive intracranial hemorrhage. She begins to seize and dies on the table, but the doctors manage to save her baby. The father is in critical condition, but with Stephanie's help, Meredith is able to keep her successful streak going. Arizona shows signs of jealousy when she sees Callie kissing another woman, but it turns out that the woman is a crazy ex-girlfriend of Arizona's. Richard tells Maggie about Ellis' fight with Alzheimer's and Maggie says that she knows she is genetically predisposed to the Alzheimer's gene. April and Jackson struggle to move on with their love life after the death of their baby, but April assures Jackson that she is no longer fragile. Meredith frets that Derek is cheating on her, but Callie, Alex, and Maggie promise he is not. After not answering his phone all day, Derek shows up on their doorstep, acknowledging that a woman answered his phone.
- "We teach residents when you hear hoof beats think horses, not zebras. It means that the most obvious answer is most usually right. It keeps doctors from heading down the wrong path. It helps us stick to the truth. It helps us save lives. It's part of what makes me a good surgeon. When I hear hoof beats, horses, I always think horses. Even when I shouldn't"
- "Ex's & Oh's" - Elle King
- "Find A Place" - IKO
- "Once" - Ed Sheeran
This episode's title originated from the song Don't Dream It's Over, originally sung by Crowded House.