"Don't Dream It's Over" is the sixteenth episode of the eleventh season of Grey's Anatomy and the 236th produced episode of the series. It is also the 347th produced episode of the Grey's Anatomy franchise. It was broadcast on March 19, 2015.
After a phone call to her husband is answered by an unknown woman, Meredith turns to her friends for support to stop herself from assuming the worst of Derek. Meanwhile, a patient with Alzheimer's is admitted into the hospital under Richard's care but Amelia believes she can change his life, prompting Richard to question whether or not to tell Maggie about her genetic predisposition to the disease. Arizona discovers that Callie is dating again and April and Jackson both try to resume some normality in their relationship.
- "We teach residents when you hear hoof beats think horses, not zebras. It means that the most obvious answer is most usually right. It keeps doctors from heading down the wrong path. It helps us stick to the truth. It helps us save lives. It's part of what makes me a good surgeon. When I hear hoof beats, horses, I always think horses. Even when I shouldn't"
- "Things are not always what they appear to be, they are often an indicator of something bigger going on deep underneath. Symptoms, red flags, warning signs, things we should pay attention to, things we shouldn't ever ignore. Things that are bad, things that could really hurt us. Things that it just might be too late to fix."
- "Ex's & Oh's" - Elle King
- "Find A Place" - IKO
- "Once" - Ed Sheeran
This episode's title originated from the song Don't Dream It's Over, originally sung by Crowded House.