"Dream A Little Dream Of Me, Part 1" is the first episode of the fifth season of Grey's Anatomy and the 79th produced episode of the series. It is also the 88th produced episode of the Grey's Anatomy franchise. It was broadcast on September 25, 2008.
Meredith questions if she and Derek can have a happily ever after in the wake of their reunion while Cristina tries to force Meredith to see that she and Derek, once again, will not work together. The doctors are rocked by the news that the hospital's ranking has fallen significantly while Mark taunts Lexie about her feelings for George. An incoming trauma brings Major Owen Hunt to the hospital and his radical idea to save Callie and Derek's patient causes conflict while Alex and Izzie's newfound friendship develops.
- "We all remember the bedtime stories of our childhood. The shoe fits Cinderalla, the frog turns into a prince, Sleeping Beauty is awakened with a kiss. Once upon a time and then they lived happily ever after. Fairy tales, the stuff of dreams. The problem is fairy tales don't come true. It's the other stories, the ones that begin with dark and stormy nights and end in the unspeakable. It's the nightmares that always seem to become reality. The person that invented the phrase happily ever after should have his ass kicked so hard."
- "Black Tables" - Other Lives
- "Youthless" - Beck
- "Wins" - Jade McNelis
- "Jungle Drum" - Emiliana Torrini
This episodes' title references the song Dream A Little Dream Of Me, originally sung by The Papas & The Mamas