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Mrs. Bryce was the mother of Meredith's first ever patient, Katie Bryce.
Personal life
Bryce travelled with her husband to Seattle Grace Hospital wen his daughter Katie was admitted there. She was extremely worried about her and frustrated with Dr. Shepherd when he could not find out what was wrong with her. Eventually, Meredith and Cristina found out and saved Katie's life.
Romantic life
Mrs. Bryce married and with her husband, she had one daughter.