"Let It Be" is the eighth episode of the second season of Grey's Anatomy and the 17th produced episode of the series. It is also the 17th produced episode of the Grey's Anatomy franchise. It was broadcast on November 13, 2005.
Derek and Addison's professional and personal relationship is challenged when their friends from Manhattan come to Seattle Grace seeking a radical, preemptive operation to avoid breast and ovarian cancer. Meanwhile, Meredith's view on love is questioned, George fails to understand why a patient who fell five stories doesn’t seem happy to have survived and Cristina and Burke attempt to have a normal date. The Shepherd's case brings issues in Izzie and Alex's budding relationship to the forefront after their kiss and Richard pushes Bailey for an answer regarding her fellowship offer.
- "In the eigth grade my English class had to read Romeo And Juliet. Then, for extra credit, Mrs. Snyder made us act out all the parts. Sal Scafarillo was Romeo. As fate would have it, I was Juliet. All the other girls were jealous but I had a slightly different take. I told Mrs. Snyder that Juliet was an idiot. For starters she falls for the one guy she knows she can't have and then she blames fate for her own bad decision. Mrs. Snyder explained to me that when fate comes into play choice sometimes goes out the window. At the ripe, old age of thirteen I was very clear that life, like love, is full of choices and fate has nothing to do with it."
- "Maybe Romeo and Juliet were fated to be together but just for a while, and then there time past. If they could have known that beforehand maybe it all could have been okay. I told Mrs. Snyder that when I was grown up I'd take fate into my own hands, I wouldn't let some guy drag me down. Mrs. Snyder said I'd be lucky if I ever had that kind of passion with someone and, if I did, we'd be together forever. Even now I believe that, for the most part, love is about choices. It's about putting down the poison and the dagger and making your own happy ending, most of the time. And that sometimes, despite your best choices and all your best intentions, fate wins anyway."
- "Sexy Mistake" - The Chalets
- "No Sleep Tonight" - The Faders
- "Bang Bang To The Rock 'n' Roll" - Gabin
- "I Melt With You" - Nouvelle Vague
- "Far Away Blues" - Nouvelle Vague
- "Miss Halfway" - Anya Marina
This episodes' title references the song Let It Be, originally sung by The Beatles