"Losing My Religion" is the twenty-seventh episode of the second season of Grey's Anatomy and the 36th produced episode of the series. It is also the 36th produced episode of the Grey's Anatomy franchise. It was broadcast on May 15, 2006.
Richard interrogates the interns to find out who is responsible for cutting Denny’s LVAD wire and Meredith, George, Alex and Meredith all band together to protect Izzie, whose receives an unexpected offer from a recovering Denny. Tension between Meredith and Derek reaches boiling point after they are forced to make a choice about Doc, leaving Addison and Finn sidelined. Burke and Cristina try to navigate their relationship following his surgery after Burke finds a tremor in his injured hand and Callie reacts adversely when George doesn’t respond to her declaration of love.
The interns are pulled into the Chief's Office, demanding to know who cut the LVAD as Denny recovers from a successful transplant. Unfortunately for Richard, the interns have their own pressing issues, so he punishes them by organizing a prom for his niece. Everyone has a choice, Meredith between two men, Izzie to tell the truth, and Derek and Meredith choose to put Doc down.
- "Under The Waves" - Pete Droge
- "Side 2" - Dressy Bessy
- "Colors" - Amos Lee
- "Destination Vertical" - Masha Qrella
- "Grace" - Kate Havnevik
- "Chasing Cars" - Snow Patrol
This episodes' title references the album Losing My Religion, originally sung by R.E.M
- This episode features no opening or closing voiceover.