Meredith is the daughter of the brilliant and famed surgeon Ellis Grey, but her childhood took a backseat to Ellis' career, leading her to endure distant and cold early years. Her mother drove her father, Thatcher Grey, away with her determination and through her affair with Richard Webber, leaving Meredith alone with her distant mother as Thatcher stopped trying to be in his daughter's life and started a new family. After the affair ended, Ellis tried to kill herself and she was saved by Meredith, but the event left her scarred.
After completing her undergraduate degree at Dartmouth College, she backpacked around Europe with Sadie Harris after attending Dartmouth, but eventually came home and decided to attend medical school, something her mother greatly disproved of. She persevered and eventually succeed in completing medical school in spite of Ellis's Alzheimer's diagnosis.
The night before she began her internship at Seattle Grace Hospital, having moved back to Seattle to care for her mother, she met Derek Shepherd and the two had a one night stand although Meredith was determined that was all it would be.
Grey's Anatomy, Season 1Edit
Grey's Anatomy, Season 2Edit
Grey's Anatomy, Season 3Edit
Grey's Anatomy, Season 4Edit
Grey's Anatomy, Season 5Edit
Grey's Anatomy, Season 6Edit
Grey's Anatomy, Season 7Edit
Grey's Anatomy, Season 8Edit
Grey's Anatomy, Season 9Edit
Grey's Anatomy, Season 10Edit
Grey's Anatomy, Season 11Edit
Grey's Anatomy, Season 12Edit
Grey's Anatomy, Season 13Edit
Grey's Anatomy, Season 14Edit
Meredith has a romantic bond with the world class surgeon Dr. Derek Shepherd since the beginning of the show, they had a one night stand the night before she began her internship at Seattle Grace Hospital. She refuses to go out with him in the beginning because he is her boss and it is highly inappropriate.
Meredith is devastated when, at the end of the first season, Derek's wife, Addison, showed up at the Hospital. It is later revealed that they were separated because Addison cheated on Derek with his friend, Dr. Mark Sloan. After Addison gives Derek the divorce papers, he decides to try to rebuild their marriage, leaving Meredith heartbroken.
When Derek doesn't choose her over his wife, Meredith begins to have a series of one night stands, including one with Dr. George O'Malley who had feelings for her since he first met her.
After Addison and Derek's efforts to rebuild their marriage begin to fail, Derek and Meredith have sex and Addison finds Meredith's panties in Derek's tuxedo pocket, finally putting an end to their marriage.
Meredith was dating a veterinarian, Finn Dandridge, when she had sex with Derek. Derek tells her she has a choice to make. Meredith is fed up with trying to decide so she begins to date them both. Meredith later decides to choose Derek, but before she could say anything, he decides that Finn is a better man for Meredith and walks away.
They later reconcile but once again break-up because Meredith is unable to commit to their relationship. Derek begins dating a nurse, Rose, but he and Meredith decide they are meant to be later on in the season and make-up after their clinical trial reaches success. She builds Derek a house of candles, showing she can commit.
In the next season Derek has a rough patch with a patient, showing his "Dark Side", he makes her a couple of marriage proposals that were unsatisfying, but later they decide to get married, the ceremony doesn't happen because they give it to their close friends, Dr. Isobel Stevens and Dr.Alex Karev. They get married on a post-it.
After Meredith and Derek discover that Meredith has medical issues with conceiving children they decide to adopt a baby, Zola, that came from Africa for a surgery in a program that was organized by Dr. Alex Karev. In order to adopt they decide to get legally married.
When they get the baby Derek finds out Meredith tampered with their clinical trial to help Dr. Richard Webber's wife, Adele, who was presenting with Alzheimer's. They are briefly separated but later on reconcile after their baby is taken away from them when the adoption agency representative finds out they were separated and that Meredith lost her job (for a brief amount of time) putting their parenting into question. Derek is still a angry at Meredith but at the middle of the season they manage to get their baby back and become happy again.
After the plane crash on the seaosn 8 finale, Meredith helps Derek to deal with his injured hand, encouraging him to get it fixed and calling his sisters to see if they would donate nerves for a surgery. Derek describes Meredith as not being "Dark and Twisty" anymore, he says now she is "Optimistic". In the beginning of season nine Meredith also reveals she is pregnant and is able to deal with her insecurities because of the risks of her pregnancy. Currently on the show Derek had surgery on his hand and is operating normally and Meredith is in the second trimester of her pregnancy.
In the beginning of her internship Meredith is described by the Chief of Surgery as being just like her mother, an extraordinary surgeon. She always appeared to be a good intern, she won a competition for the "Sparkle Pager" that would give her an opportunity to get to participate in many surgeries.
She passed her intern exams and began to develop an interest for Neuro, but she had to stop because it was deeply affecting her marriage with Dr. Derek Shepherd, her husband and mentor. She spent some time delivering babies but after being called attention by the new chief, Dr. Owen Hunt as he suspected she was "sinking", she decides to pursue the same specialty as her mother, General Surgery.
With the help of Dr.Richard Webber she convinced Dr. Callie Torres to train her for the Medical Boards and even though she was sick during the examination she passed and decided to be a fellow at Seattle Grace Mercy West Hospital, working alongside with Dr. Richard Webber and Dr. Miranda Bailey.
She is the attending that is most feared by the interns, she is called "Medusa" because as one of her interns said, "She is a monster of mythic proportions". She also appears to be an extraordinary surgeon because in her first year as an attending she was able to remove an extremely rare tumor with no help.