"Puzzle With A Piece Missing" is the second episode of the eleventh season of Grey's Anatomy and the 222nd produced episode of the series. It is also the 333rd produced episode of the Grey's Anatomy franchise. It was broadcast on Octobter 2, 2014.
Maggie continues to find her niche at Grey Sloan Memorial Hospital as she continues to navigate the personal and professional complications of her secret lineage, especially as she and Meredith continue to clash especially when the come to blows over Maggie's treatment of an elderly patient wishing to die on her own terms. Meanwhile, Owen struggles to let Maggie out of Cristina's shadow when he discovers she is still investigating Cristina's last patient's condition while Jo inadvertently jeopardizes Alex's future when she discloses his board seat nomination to Maggie, which leads to his practice discovering the truth. Callie and Arizona continue to disagree on whether they should persue a surrogacy or whether Arizona should accept her fellowship while, both aware of Maggie's parentage, Richard and Amelia both try to find their own ways to push Maggie towards connecting with Meredith.
- "I love puzzles, ever since I was a kid. My record for the Friday New York Times crossword is eleven minutes. I'm still trying to beat that. Ok, that sounds braggy, I just mean once I pick a puzzle up I can't put it down until it's solved. I think puzzles are why I went into medicine. That's mostly what medicine is; gather all available information, assess the problem, you focus your attention and you solve the puzzle. People are a harder puzzle. There's never one right answer. You never have all of the information."
- "Most puzzles come down to one last missing piece of information whether it's the answer to a medical mystery or to the question of who you are, where you fit. It all comes down to that last piece. That's why the final piece of a jigsaw puzzle is so satisfying. Unless of course the piece doesn't quite fit. That can make you wish you'd never opened the puzzle in the first place."
- "Everybody Wants You" - Billy Squier
This episode's title originated from the song Puzzle With A Piece Missing, originally sung by Gotye.
- Maggie narrates the voiceover for episode.