"Sanctuary" is the twenty-third episode of the sixth season of Grey's Anatomy and the 125th produced episode of the series. It is also the 179th produced episode of the Grey's Anatomy franchise. It was broadcast on May 30, 2010.
Seattle Grace is hit with a crisis like no other in it's history which leaves the lives of the doctors hanging in the balance while a shooter roams the halls, gunning for Derek who he holds responsible for the death of his wife. Amidst the crisis, Meredith discovers life-changing news at an inopportune time and Cristina makes a choice about her relationship with Owen after they reach crossroads. Mark and Lexie are forced to work together in a difficult situation while the lock-down forces Callie and Arizona's issues.
- "For most people a hospital is a scary place, a hostile place. A place where bad things happen. Most people would prefer church or school or home but I grew up here. While my mom was on rounds I learned to read in the O.R gallery, I played in the morgue, I colored with crayons on old E.R charts. The hospital was my church, my school, my home. The hospital was my safe place, my sanctuary. I love it here. Correction, loved it here."
- "I learned to read in the O.R gallery, I played in the morgue, I colored with crayons on old E.R charts. The hospital was my church, my school, my home, my safe place, my sanctuary. I love it here. Correction, loved it here."
- "Holding Us Back" - Katie Herzig
- "How The Heart Grows Wicked" - Patrick Park
This episodes' title references the song Sanctuary, originally sung by Iron Maiden