"Something's Gotta Give" is the eighth episode of the seventh season of Grey's Anatomy and the 134th produced episode of the series. It is also the 195th produced episode of the Grey's Anatomy franchise. It was broadcast on November 11, 2010.
Top security measures go into place as a team of doctors, led by the Chief and Teddy, try to save the life of a major political figure from the Middle East while, after finding themselves both unemployed, Cristina and Callie throw a housewarming party. Alex shows up late from a weekend getaway to his first day of rounds with the new pediatrics attending, Robert Stark while April defies her friends warnings to stay away from Alex. Jackson begins to feel paranoid that his fellow doctors don't want to work with him.
- "The human body is a highly pressurized system. The blood pressure measures the force of blood pulsating through the arteries. It's important to keep this pressure regulated. Low or inadequate pressure can cause weakness or failure. It's when the pressure gets too high that problems really occur. If the pressure continues to increase a closer examination is called for because it's the best indicator that something is going terribly wrong."
- "Every pressurized system needs a release valve. There has to be a way to reduce the stress, the tension before it becomes too much to bear. There has to be a way to find relief because if the pressure doesn't find a way out it'll make one. It will explode. It's the pressure we put on ourselves that's the hardest to bear. The pressure to be better than we are, the pressure to be better than we think we can be. It never, ever lets up. It just builds and builds and builds."
- "Gone Man" - Eels
- "Dead Disco" - Metric
- "Shouldn't Have Loved" - Azure Ray
- "Dreamer" - K'naan
- "Could It Be" - Mackintosh Braun
- "Sing Me To Sleep" - Fran Healy feat. Neko Case
This episodes' title references the song Something's Gotta Give, originally sung by Frank Sinatra