"The First Cut Is The Deepest" is the second episode of the first season of Grey's Anatomy and the 2nd produced episode of the series. It is also the 2nd produced episode of the Grey's Anatomy franchise. It was broadcast on April 3, 2005.
- "It's all about lines. The finishing line at the end of residency, waiting in line for a chance at the operating table. And then there's the most important line - the line seperating you from the people you work with. It doesn't help to get too familiar, to make friends. You need boundaries between you and the rest of the world. Other people are far too messy. It's all about lines. Drawing lines in the sand and praying like hell no one crosses them."
- "At some point you have to make a decision. Boundaries don't keep other people out, they fence you in. Life is messy, that's how we're made. So you can waste your life drawing lines or you can live your life crossing them. But there are some lines that are way too dangerous to cross. Here's what I know, if you're willing to take the chance the view from the other side is spectacular."
The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile, Meredith puts her career on the line to save a newborn in the hospital nursery; while taking on the responsibility of an object that she wished she never had to look after and George, Alex, Cristina and Izzie learn that it takes more than just medical knowledge to be good at their jobs.
- "You Wouldn't Like Me" - Tegan And Sara
- "Sister Kate" - The Ditty Bops
- "Live and Learn" - The Cardigans
- "Wait" - Get Set Go
- "Somewhere Only We Know" - Keane
This episodes' title references the song The First Cut Is The Deepest, originally sung by Cat Stevens