"Two Against One" is the eighth episode of the tenth season of Grey's Anatomy and the 204th produced episode of the series. It is also the 315th produced episode of the Grey's Anatomy franchise. It was broadcast on November 7, 2013.
When Meredith reaches a milestone on her research project, she finds herself continuing to try and prove her worth as a doctor in the wake of her and Cristina's disagreement while Cristina and Shane look for a miracle cure for their patient, a search which sends Meredith and Cristina on a collision course, while Alex finds himself caught in the middle of their argument. Meanwhile, still dealing with Ben's return to the hospital, Bailey begins to exhibit worrying behaviour in the O.R while Owen offers his new girlfriend, Emma, a job at Grey Sloan Memorial Hospital. Meanwhile, Derek pushes Jackson to relinquish control and let the second year residents operate on his patients and April and Matthew make a decision about the future of their relationship with tests April.
- "Glioma, fibroma, blastoma. Whatever the tumour, people assume approach it the same way. You find it's hiding place in the body and open the patient up and you cut it the hell out. But you're not just fighting the one tumour. You're actually at war with over a billion cells."
- "So how do you beat the odds when it's one against a billion? You stand strong, keep pushing yourself past all rational limits and never let yourself give up. But the truth of the matter is, despite how hard you try and fight to stay in control, when it's all said and done sometimes you're just outnumbered."
- "Bravado" - Lorde
- "Right Here" - Rudimental feat. Foxes
This episode's title originated from the song Two Against One, originally sung by Danger Mouse.